Restoration of anatomical continuity after spinal cord transection depends on Wnt/beta-catenin signaling in larval zebrafish

被引：10

作者：

Wehner, Daniel ^{[1
]}

Becker, Thomas ^{[1
]}

Becker, Catherina G. ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Neuroregenerat, Chancellors Bldg,49 Little France Crescent, Edinburgh EH16 4SB, Midlothian, Scotland

来源：

DATA IN BRIEF | 2018年 / 16卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Wnt; Beta-catenin; Regeneration; Spinal cord; Zebrafish;

D O I：

10.1016/j.dib.2017.10.068

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This data article contains descriptive and experimental data on spinal cord regeneration in larval zebrafish and its dependence on Wnt/beta-catenin signaling. Analyzing spread of intraspinally injected fluorescent dextran showed that anatomical continuity is rapidly restored after complete spinal cord transection. Pharmacological interference with Wnt/beta-catenin signaling (IWR-1) impaired restoration of spinal continuity. For further details and experimental findings please refer to the research article by Wehner et al. Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish (Wehner et al., 2017) [1]. (C) 2017 The Authors. Published by Elsevier Inc.

引用

页码：65 / 70

页数：6

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