EFFICACY OF LIVE-ATTENUATED AND WHOLE-INACTIVATED SIMIAN IMMUNODEFICIENCY VIRUS-VACCINES AGAINST VAGINAL CHALLENGE WITH VIRULENT SIV

被引：0

作者：

MARTHAS, ML

MILLER, CJ

SUTJIPTO, S

HIGGINS, J

TORTEN, J

LOHMAN, BL

UNGER, RE

RAMOS, RA

KIYONO, H

MCGHEE, JR

MARX, PA

PEDERSEN, NC

机构：

[1] UNIV CALIF DAVIS, DEPT VET MED, DAVIS, CA 95616 USA

[2] UNIV CALIF DAVIS, DEPT MED PATHOL, DAVIS, CA 95616 USA

[3] UNIV ALABAMA, DEPT ORAL BIOL, BIRMINGHAM, AL 35294 USA

[4] UNIV ALABAMA, DEPT MICROBIOL, BIRMINGHAM, AL 35294 USA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1992年 / 21卷 / 2-3期

关键词：

HIV; SIV; GENITAL MUCOSA; SIV-SPECIFIC VAGINAL ANTIBODIES; RHESUS MACAQUES;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.

引用

页码：99 / 107

页数：9