P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II

被引：35

作者：

Li, You ^{[1
]}

Liu, Min ^{[1
]}

Chen, Lin-Feng ^{[2
]}

Chen, Ruichuan ^{[1
]}

机构：

[1] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361101, Peoples R China

[2] Univ Illinois, Coll Med, Dept Biochem, Urbana, IL 61801 USA

来源：

TRANSCRIPTION-AUSTIN | 2018年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

7SK snRNP; Brd4; KAP1; promoter-proximal pausing; P-TEFb; RNA Pol II; SEC; transcription elongation;

D O I：

10.1080/21541264.2017.1281864

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.

引用

页码：88 / 94

页数：7

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