1,2,4-TRIAZOLES .6. SYNTHESIS OF NEW 1,5-DIPHENYL-3-1H-1,2,4-TRIAZOLES SUBSTITUTED WITH H-, ALKYL, OR CARBOXYL GROUPS AT C-3

被引：45

作者：

CZOLLNER, L

SZILAGYI, G

LANGO, J

JANAKY, J

机构：

[1] Institute for Drug Research, Budapest, H-1325

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 04期

关键词：

D O I：

10.1002/ardp.19903230409

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Amidines obtained from benzamides and DMF‐ or DMA‐dimethylacetal were cyclized with phenylhydrazines to 3H‐ or 3‐methyltriazoles. 3‐Ethyltriazoles were synthesized from diacylamides. Triazole‐3‐carboxylic acides were prepared starting from anilines. The compounds were assayed in the rat adjuvant induced arthritis model. Some compounds show significant anti‐inflammatory activity. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

收藏

页码：225 / 227

页数：3

相关论文

共 12 条

[1] Hydrizino-halides derived from oxalic acid. [J].

Bowack, DA ;

Lapworth, A .

JOURNAL OF THE CHEMICAL SOCIETY, 1905, 87 :1854-1869

[2] 1,2,4-TRIAZOLES .3. NEW 1,5-DIARYL-3-(SUBSTITUTED AMINO)-1H-1,2,4-TRIAZOLES AS ANTIINFLAMMATORY AGENTS [J].

BOZO, E ;

SZILAGYI, G ;

JANAKY, J .

ARCHIV DER PHARMAZIE, 1989, 322 (10) :583-587

[3] ACID AMIDE-REACTIONS L - ORTHO-AMIDES .I. SYNTHESIS AND PROPERTIES OF AMIDE ACETALES AND AMINALESTERS [J].

BREDERECK, H ;

SIMCHEN, G ;

REBSDAT, S ;

KANTLEHNER, W ;

HORN, P ;

WAHL, R ;

HOFFMANN, H ;

GRIESHABER, P .

CHEMISCHE BERICHTE-RECUEIL, 1968, 101 (01) :41-+

[4] 1,2,4-TRIAZOLES .2. SYNTHESIS OF 1,5-DIPHENYL-3-TRIFLUOROMETHYL-1H-1,2,4-TRIAZOLES [J].

CZOLLNER, L ;

SZILAGYI, G ;

LANGO, J ;

JANAKY, J .

MONATSHEFTE FUR CHEMIE, 1988, 119 (03) :349-353

[5] 1,2,4-TRIAZOLES .5. A FACILE SYNTHESIS OF 1,5-DIPHENYL-3-(SUBSTITUTED OXY)-1H-1,2,4-TRIAZOLES [J].

CZOLLNER, L ;

SZILAGYI, G ;

LANGO, J ;

JANAKY, J .

ARCHIV DER PHARMAZIE, 1990, 323 (04) :221-223

[6] SYNTHESIS OF S-TRIAZINES BEARING 3 DIFFERENT SUBSTITUENTS [J].

LIN, Y ;

FIELDS, TL ;

LEE, VJ ;

LANG, SA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1982, 19 (03) :613-615

[7] NEW SYNTHESIS OF 1,2,4-TRIAZOLES AND 1,2,4-OXADIAZOLES [J].

LIN, YI ;

LANG, SA ;

LOVELL, MF ;

PERKINSON, NA .

JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (23) :4160-4164

[8]

MASATAKE T, 1977, Patent No. 125141

[9] CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT [J].

NEWBOULD, BB .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1963, 21 (01) :127-&

[10]

STANLEY L, 1981, Patent No. 4259504