TRANSPORT-SYSTEMS FOR POLYAMINES IN THE ESTABLISHED RENAL-CELL LINE LLC-PK1 - POLARIZED EXPRESSION OF AN NA+-DEPENDENT TRANSPORTER

被引：18

作者：

VANDENBOSCH, L ^{[1
]}

DESMEDT, H ^{[1
]}

MISSIAEN, L ^{[1
]}

PARYS, JB ^{[1
]}

BORGHGRAEF, R ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,PHYSIOL LAB,CAMPUS GASTHUISBERG,B-3000 LOUVAIN,BELGIUM

来源：

BIOCHEMICAL JOURNAL | 1990年 / 265卷 / 02期

关键词：

D O I：

10.1042/bj2650609

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present evidence for the existence of an Na+-dependent transporter and an Na+-independent transporter for polyamines in LLC-PK1 cells. Both transporters could be discriminated by their sensitivity to inhibitors, particularly p-chloromercuriphenyl sulphate and various polycationic molecules. By using cell monolayers grown on a permeable filter support, we may have found that the Na+-dependent polyamine uptake occurred preferentially from the basolateral side. The Na+-independent uptake, on the other hand, occurred to the same extent from either the apical or the basolateral side.

引用

页码：609 / 612

页数：4

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