DEXAMETHASONE STIMULATION OF METALLOTHIONEIN SYNTHESIS IN HELA-CELL CULTURES

被引：136

作者：

KARIN, M ^{[1
]}

HERSCHMAN, HR ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, INST MOLEC BIOL, DEPT BIOL CHEM, LOS ANGELES, CA 90024 USA

来源：

SCIENCE | 1979年 / 204卷 / 4389期

关键词：

D O I：

10.1126/science.432639

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

HeLa cells in culture synthesize metallothionein. To investigate the effects of glucocorticoids on metallothionein synthesis we adapted HeLa cells to growth in a defined medium lacking hydrocortisone. In this defined medium, containing 1.5 × 10-6M Zn2+, dexamethasone (10 -6M) caused a five- to sixfold increase in the synthesis of metallothionein. Progesterone (10-5M), a known antagonist of glucocorticoids, inhibited this response by 50 percent. Copyright © 1979 AAAS.

引用

页码：176 / 177

页数：2

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