IDIOPATHIC INFLAMMATORY MYOPATHY OF THE ANTISYNTHETASE (JO-1) TYPE ASSOCIATED WITH NONCASEATING GRANULOMAS

被引：12

作者：

MODER, KG

GAFFEY, TA

MATTESON, EL

机构：

[1] MAYO CLIN & MAYO FDN,DIV RHEUMATOL,E15,200 1ST ST SW,ROCHESTER,MN 55905

[2] MAYO CLIN & MAYO FDN,DEPT PATHOL,ROCHESTER,MN 55905

来源：

ARTHRITIS AND RHEUMATISM | 1993年 / 36卷 / 12期

关键词：

D O I：

10.1002/art.1780361215

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The idiopathic inflammatory myopathies are a heterogeneous group of syndromes that share the finding of chronic muscle inflammation. Recently, serologic subtyping of autoantibodies found in patients with these syndromes has been used to identify distinct clinical entities. We describe a 36-year-old woman who, based on the findings of polymyositis documented by both electromyography and muscle biopsy, features of Raynaud's phenomenon, symmetric polyarthritis, ''mechanic's hands,'' and Jo-1 antibody positivity, was considered to have the antisynthetase subset of idiopathic inflammatory myopathy. In addition, the patient had granulomatous synovitis, and noncaseating granulomas were found in a breast nodule. This is the first published report of granuloma formation in the antisynthetase syndrome.

引用

页码：1743 / 1747

页数：5

共 23 条

[1]

Plotz PH, Dalakas M, Leff RL, Love LA, Miller FW, Cronin ME, Current concepts in the idiopathic inflammatory myopathies: polymyositis, dermatomyositis, and related disorders, Ann Intern Med, 111, pp. 143-157, (1989)

[2]

Love LA, Leff RL, Fraser DD, Targoff IN, Dalakas M, Plotz PH, Miller FW, A new approach to the classification of idiopathic inflammatory myopathy, Medicine, 70, pp. 360-374, (1991)

[3]

Maguerie C, Bunn CC, Beynon HL, Bernstein RM, Hughes JM, So AK, Walport MJ, Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl‐tRNA sythetase enzymes, QJM, 77, pp. 1019-1038, (1990)

[4]

Bohan A, Peter JB, Polymyositis and dermatomyositis (parts 1 and 2), N Engl J Med, 292, pp. 344-347, (1975)

[5]

Miller FW, (1991)

[6]

Oddis CV, Medsger TA, Cooperstein LA, A subluxing arthropathy associated with the anti–Jo‐1 antibody in polymyositis‐dermatomyositis, Arthritis Rheum, 33, pp. 1640-1645, (1990)

[7]

Bunch TW, O'Duffy JD, McLeod RA, Deforming arthritis of the hands in polymyositis, Arthritis Rheum, 19, pp. 243-247, (1976)

[8]

Cohen MG, Ho KK, Webb J, Finger joint calcinosis followed by osteolysis in a patient with multisystem connective tissue disease and anti‐Jo1, J Rheumatol, 14, (1987)

[9]

Tazelaar HD, Viggiano RW, Pickersgill J, Colby TV, Interstitial lung disease in polymyositis and dermatomyositis, Am Rev Resp Dis, 141, pp. 727-733, (1990)

[10]

Yoshida S, Akizuki M, Mimori T, Yamagata H, Inada S, Homma M, The precipitating antibody to an acidic nuclear protein antigen, the Jo‐1, in connective tissue disease: a marker for a subset of polymyositis with interstitial pulmonary fibrosis, Arthritis Rheum, 26, pp. 604-611, (1983)

← 1 2 3 →