STEROL MOLECULE - STRUCTURE, BIOSYNTHESIS, AND FUNCTION

被引:200
作者
BLOCH, K
机构
关键词
STEROLS; CHOLESTEROL; BIOLOGIC SYNTHESIS; HISTORY OF CHEMICAL STRUCTURE;
D O I
10.1016/0039-128X(92)90081-J
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review briefly summarizes key researches on the structure of the sterol molecule from its very beginnings to the definitive elucidation in 1932. Cholesterol biosynthesis treated in somewhat greater detail covers the period from the 1930s to the 1960s. As a historic contribution, it presents researches previously published in numerous books, reviews, and original papers. The selection of topics, dictated by limits of time and space, is necessarily arbitrary and a personal choice. Readers of this journal will be familiar with the relevant chemical structures. Structural formulas are therefore omitted.
引用
收藏
页码:378 / 383
页数:6
相关论文
共 44 条
[1]   THE ENZYMATIC CONVERSION OF MEVALONIC ACID TO SQUALENE [J].
AMDUR, BH ;
RILLING, H ;
BLOCH, K .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (10) :2646-2647
[2]  
[Anonymous], 2012, METHODS ECOL EVOL, DOI DOI 10.1111/j.2041-210X.2011.00169.x
[3]   Crystal structures of vitamin D and related compounds [J].
Bernal, JD .
NATURE, 1932, 129 :277-278
[4]  
Blanc HG, 1907, CR HEBD ACAD SCI, V144, P1356
[5]  
Bloch K, 1942, J BIOL CHEM, V145, P625
[6]   THE STRUCTURE OF CHOLESTEROL AND OF THE BILE-ACIDS [J].
BLOCH, K .
TRENDS IN BIOCHEMICAL SCIENCES, 1982, 7 (09) :334-336
[8]  
CASTELLS J, 1956, CHEM IND, V14, P248
[10]   PHOSPHORYLATED INTERMEDIATES IN THE SYNTHESIS OF SQUALENE [J].
CHAYKIN, S ;
LAW, J ;
PHILLIPS, AH ;
TCHEN, TT ;
BLOCH, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1958, 44 (10) :998-1004