Prevention of Exacerbations in Chronic Obstructive Pulmonary Disease: Knowns and Unknowns

被引：22

作者：

Agusti, Alvar ^{[1
]}

Calverley, Peter M. ^{[2
]}

Decramer, Marc ^{[3
]}

Stockley, Robert A. ^{[4
]}

Wedzicha, Jadwiga A. ^{[5
]}

机构：

[1] Hosp Clin Barcelona, Inst Torax, Villarroel 170,Escala 3 Planta 5, Barcelona 08036, Spain

[2] Aintree Univ Hosp NHS Fdn Trust, Ctr Clin Sci, Liverpool, Merseyside, England

[3] Univ Hosp, Div Resp, Leuven, Belgium

[4] Univ Hosp Birmingham, Lung Invest Unit, Birmingham, W Midlands, England

[5] Imperial Coll London, Airways Dis Sect, Natl Heart & Lung Inst, London, England

来源：

CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION | 2014年 / 1卷 / 02期

关键词：

COPD; exacerbations; chronic bronchitis; emphysema; smoking; inflammation; therapy;

D O I：

10.15326/jcopdf.1.2.2014.0134

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The 2011 recommendations of the Global initiative for chronic Obstructive Lung Disease (GOLD) constituted a major paradigm shift in COPD management since they set 2 major goals for the assessment and management of patients: (1) the reduction of their current level of symptoms (i.e., treat the patient today); and (2) the reduction of their risk of exacerbations (i.e., prevent them tomorrow). Exacerbations are not only an important clinical endpoint in patients with COPD, but they are also a risk factor themselves for additional adverse outcomes since they have been shown to increase the risk for mortality, to accelerate the decline in pulmonary function, and to decrease health status and quality of life. Despite their importance, many unanswered questions related to exacerbations remain. The purpose of this review is to discuss: (1) knowns and unknowns in our current understanding of exacerbations, (2) what known factors increase their risk, and (3) how to best prevent them.

引用

页码：166 / 184

页数：19

共 132 条

[1] Counting, analysing and reporting exacerbations of COPD in randomised controlled trials [J].

Aaron, S. D. ;

Fergusson, D. ;

Marks, G. B. ;

Suissa, S. ;

Vandemheen, K. L. ;

Doucette, S. ;

Maltais, F. ;

Bourbeau, J. F. ;

Goldstein, R. S. ;

Balter, M. ;

O'Donnell, D. ;

FitzGerald, M. .

THORAX, 2008, 63 (02) :122-128

[2] Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease - A randomized trial [J].

Aaron, Shawn D. ;

Vandemheen, Katherine L. ;

Fergusson, Dean ;

Maltais, Francois ;

Bourbeau, Jean ;

Goldstein, Roger ;

Balter, Meyer ;

O'Donnell, Denis ;

McIvor, Andrew ;

Sharma, Sat ;

Bishop, Graham ;

Anthony, John ;

Cowie, Robert ;

Field, Stephen ;

Hirsch, Andrew ;

Hernandez, Paul ;

Rivington, Robert ;

Road, Jeremy ;

Hoffstein, Victor ;

Hodder, Richard ;

Marciniuk, Darcy ;

McCormack, David ;

Fox, George ;

Cox, Gerard ;

Prins, Henry B. ;

Ford, Gordon ;

Bleskie, Dominique ;

Doucette, Steve ;

Mayers, Irvin ;

Chapman, Kenneth ;

Zamel, Noe ;

FitzGerald, Mark .

ANNALS OF INTERNAL MEDICINE, 2007, 146 (08) :545-U15

[3] TNFα antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial [J].

Aaron, Shawn D. ;

Vandemheen, Katherine L. ;

Maltais, Francois ;

Field, Stephen K. ;

Sin, Don D. ;

Bourbeau, Jean ;

Marciniuk, Darcy D. ;

FitzGerald, J. Mark ;

Nair, Parameswaran ;

Mallick, Ranjeeta .

THORAX, 2013, 68 (02) :142-148

[4] Inhaled Corticosteroids vs Placebo for Preventing COPD Exacerbations A Systematic Review and Metaregression of Randomized Controlled Trials [J].

Agarwal, Ritesh ;

Aggarwal, Ashutosh N. ;

Gupta, Dheeraj ;

Jindal, Surinder K. .

CHEST, 2010, 137 (02) :318-325

[5] Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype [J].

Agusti, Alvar ;

Edwards, Lisa D. ;

Rennard, Stephen I. ;

MacNee, William ;

Tal-Singer, Ruth ;

Miller, Bruce E. ;

Vestbo, Jorgen ;

Lomas, David A. ;

Calverley, Peter M. A. ;

Wouters, Emiel ;

Crim, Courtney ;

Yates, Julie C. ;

Silverman, Edwin K. ;

Coxson, Harvey O. ;

Bakke, Per ;

Mayer, Ruth J. ;

Celli, Bartolome .

PLOS ONE, 2012, 7 (05)

[6] Azithromycin for Prevention of Exacerbations of COPD [J].

Albert, Richard K. ;

Connett, John ;

Bailey, William C. ;

Casaburi, Richard ;

Cooper, J. Allen D., Jr. ;

Criner, Gerard J. ;

Curtis, Jeffrey L. ;

Dransfield, Mark T. ;

Han, MeiLan K. ;

Lazarus, Stephen C. ;

Make, Barry ;

Marchetti, Nathaniel ;

Martinez, Fernando J. ;

Madinger, Nancy E. ;

McEvoy, Charlene ;

Niewoehner, Dennis E. ;

Porsasz, Janos ;

Price, Connie S. ;

Reilly, John ;

Scanlon, Paul D. ;

Sciurba, Frank C. ;

Scharf, Steven M. ;

Washko, George R. ;

Woodruff, Prescott G. ;

Anthonisen, Nicholas R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (08) :689-698

[7] ANTIBIOTIC-THERAPY IN EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE [J].

ANTHONISEN, NR ;

MANFREDA, J ;

WARREN, CPW ;

HERSHFIELD, ES ;

HARDING, GKM ;

NELSON, NA .

ANNALS OF INTERNAL MEDICINE, 1987, 106 (02) :196-204

[8]

Anzueto A, 2009, Int J Chron Obstruct Pulmon Dis, V4, P245

[9] The Effects of Smoking Cessation on the Risk of Chronic Obstructive Pulmonary Disease Exacerbations [J].

Au, David H. ;

Bryson, Christopher L. ;

Chien, Jason W. ;

Sun, Haili ;

Udris, Edmunds M. ;

Evans, Laura E. ;

Bradley, Katharine A. .

JOURNAL OF GENERAL INTERNAL MEDICINE, 2009, 24 (04) :457-463

[10] Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease A Randomized Placebo-Controlled Trial [J].

Bafadhel, Mona ;

McKenna, Susan ;

Terry, Sarah ;

Mistry, Vijay ;

Pancholi, Mitesh ;

Venge, Per ;

Lomas, David A. ;

Barer, Michael R. ;

Johnston, Sebastian L. ;

Pavord, Ian D. ;

Brightling, Christopher E. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :48-55

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