ENDOGENOUS CHOLECYSTOKININ REDUCES FEEDING IN YOUNG-RATS

被引：122
作者：
WELLER, A
SMITH, GP
GIBBS, J
机构：
[1] CORNELL UNIV LIB, COLL MED, DEPT PSYCHIAT, ITHACA, NY 14853 USA
[2] NEW YORK HOSP, CORNELL MED CTR, EW BOURNE BEHAV RES LAB, WHITE PLAINS, NY 10605 USA
来源：
SCIENCE | 1990年 / 247卷 / 4950期
关键词：
D O I：
10.1126/science.2321020
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.
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收藏
页码：1589 / 1591
页数：3
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