PREGNANCY-ASSOCIATED PLASMA-PROTEIN-A LEVELS IN MATERNAL SERUM, EXTRAEMBRYONIC CELOMIC AND AMNIOTIC FLUIDS IN THE FIRST TRIMESTER

被引：13

作者：

ILES, RK ^{[1
]}

WATHEN, NC ^{[1
]}

SHARMA, KB ^{[1
]}

CAMPBELL, J ^{[1
]}

GRUDZINSKAS, JG ^{[1
]}

CHARD, T ^{[1
]}

机构：

[1] UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,DEPT OBSTET & GYNAECOL,LONDON EC1A 7BE,ENGLAND

来源：

PLACENTA | 1994年 / 15卷 / 07期

关键词：

D O I：

10.1016/0143-4004(94)90031-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

First trimester maternal serum levels of pregnancy-associated plasma protein A(PAPP-P) are reduced in women with a Down's syndrome pregnancy. We have examined the concentration of this molecule in the amniotic (AF) and extraembryonic coelomic (EECF) fluids surrounding the developing fetus. Maternal serum levels of PAPP-A were elevated in all samples and steadily rose from a median of 480 mIU/1 at 8 weeks to a median of 6375 mIU/1 at 14 weeks gestation. Levels of PAPP-A were low in EECF and undetectable in the AF until 14 weeks gestation. This pattern of distribution is in contrast to that of most other trophoblast-associated antigens. This may reflect PAPP-A physiology and its specific production by the syncytiotrophoblast. © 1994.

引用

页码：693 / 699

页数：7

共 24 条

[1] AMNIOTIC-FLUID AND PLASMA-CONCENTRATIONS OF PREGNANCY-ASSOCIATED PLASMA PROTEIN-A (PAPP-A) THROUGHOUT PREGNANCY - COMPARISON WITH OTHER FETOPLACENTAL PRODUCTS [J].