EFFECTS OF IMIPRAMINE AND MIRTAZAPINE ON OPERANT PERFORMANCE IN RATS

被引:12
作者
ANDREWS, JS [1 ]
JANSEN, JHM [1 ]
LINDERS, S [1 ]
PRINCEN, A [1 ]
DRINKENBURG, WHIM [1 ]
COENDERS, CJH [1 ]
VOSSEN, JHM [1 ]
机构
[1] UNIV NIJMEGEN,DEPT COMPARAT & PHYSIOL PSYCHOL,NIJMEGEN,NETHERLANDS
关键词
DELAYED MATCHING TO POSITION; DRL; VISUAL DISCRIMINATION; IMIPRAMINE; MIRTAZAPINE;
D O I
10.1002/ddr.430320109
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The effects of the tricyclic antidepressant imipramine and the atypical antidepressant mirtazapine were compared on the performance of rats in three operant procedures: a differential reinforcement of low rates schedule (DRL), a delayed matching to position (DMTP), and simultaneous visual discrimination tasks. Both compounds improved performance in the DRL task in a similar dose-related manner. Imipramine, but not mirtazapine, disrupted performance in the visual discrimination task. Imipramine reduced accuracy and increased response latencies and missed trials. Neither compound effected accuracy in the DMTP; both compounds caused some slowness of responding and imipramine caused several animals to fail to respond in a manner similar to that observed in the visual discrimination task. These data suggest that although imipramine and mirtazapine are similarly effective in putative tests of antidepressant activity, imipramine has a greater tendency to disrupt other aspects of cognitive performance, as well as exert generally depressive effects on operant responding. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码:58 / 66
页数:9
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