EVOLUTIONARY ORIGINS OF THE TRANSFORMING GROWTH-FACTOR-BETA GENE FAMILY

被引：69
作者：
BURT, DW
PATON, IR
机构：
[1] Department of Cellular and Molecular Biology, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin
来源：
DNA AND CELL BIOLOGY | 1992年 / 11卷 / 07期
关键词：
D O I：
10.1089/dna.1992.11.497
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A molecular phylogeny for the transforming growth factor-beta (TGF-beta) gene family based on a comparison of nucleotide sequences is proposed. A phylogenetic tree constructed from these sequences shows that the family evolved from a common ancestral gene that came into existence at about the time of arthropod and chordate divergence. This model suggests that the present day TGF-beta gene family consists of four members: TGF-beta-1 (= TGF-beta-4), TGF-beta-2, TGF-beta-3, and TGF-beta-5. The molecular phylogeny and Southern hybridization data also suggest that the proteins for mammalian TGF-beta-1 and chicken TGF-beta-4 are the products of homologous rather than duplicated genes. If the gene duplication event that produced the ancestral gene for TGF-beta-1 occurred before the divergence of birds and mammals, then sufficient time would have elapsed to generate these quite distinct avian and mammalian TGF-beta-1 proteins. Therefore, the TGF-beta family contains four distinct proteins, TGF-beta-1, 2, 3, and 5
引用
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页码：497 / 510
页数：14
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