A NEW COUPLING REAGENT FOR PEPTIDE-SYNTHESIS - BENZOTRIAZOLYLOXY-BIS(PYRROLIDINO)-CARBONIUM HEXAFLUOROPHOSPHATE (BBC)

被引：57
作者：
CHEN, SQ
XU, JC
机构：
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 05期
关键词：
BENZOTRIAZOLYLOXY-BIS(PYRROLIDINO)-CARBONIUM HEXAFLUOROPHOSPHATE (BBC); COUPLING REAGENT; SOLUTION AND SOLID PHASE PEPTIDE SYNTHESIS; LEU-ENKEPHALIN;
D O I：
10.1016/S0040-4039(00)92333-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzotriazolyloxy-bis (pyrrolidino)-carbonium hexafluorophosphate (BBC) is found to be a new excellent coupling reagent devoid of cytotoxic by-product instead of HBTU and BOP. It has been applied in the solution and solid phase peptide synthesis.
引用
收藏
页码：647 / 650
页数：4
相关论文
共 14 条
[1]  
CASTRO B, 1975, TETRAHEDRON LETT, P1219
[2]  
CHEN SQ, 1991, IN PRESS TETRAHEDRON
[3]   PYBOP - A NEW PEPTIDE COUPLING REAGENT DEVOID OF TOXIC BY-PRODUCT [J].
COSTE, J ;
LENGUYEN, D ;
CASTRO, B .
TETRAHEDRON LETTERS, 1990, 31 (02) :205-208
[4]  
DOURTOGLOU V, 1978, TETRAHEDRON LETT, P1269
[5]   O-BENZOTRIAZOLYL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE AS COUPLING REAGENT FOR THE SYNTHESIS OF PEPTIDES OF BIOLOGICAL INTEREST [J].
DOURTOGLOU, V ;
GROSS, B ;
LAMBROPOULOU, V ;
ZIOUDROU, C .
SYNTHESIS-STUTTGART, 1984, (07) :572-574
[6]   BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE - A NEW CONVENIENT COUPLING REAGENT FOR THE SYNTHESIS OF AMIDES AND PEPTIDES [J].
KIM, S ;
CHANG, H ;
KO, YK .
TETRAHEDRON LETTERS, 1985, 26 (10) :1341-1342
[7]   NEW COUPLING REAGENTS IN PEPTIDE CHEMISTRY [J].
KNORR, R ;
TRZECIAK, A ;
BANNWARTH, W ;
GILLESSEN, D .
TETRAHEDRON LETTERS, 1989, 30 (15) :1927-1930
[8]  
MOISAND A, 1970, ANN PHARM FR, V28, P575
[9]  
OGURA H, 1980, TETRAHEDRON LETT, P1467
[10]  
OUSTRIN ML, 1972, ANN PHARM FR, V30, P685
12