NON-SPECIFICITY OF BEHAVIORAL DESPAIR AS AN ANIMAL-MODEL OF DEPRESSION

被引：79
作者：
SCHECHTER, MD
CHANCE, WT
机构：
[1] Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 2-3期
关键词：
Behavioral model; Caffeine; Depression; Imipramine; Pentobarbital; Triiodothyronine;
D O I：
10.1016/0014-2999(79)90212-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
When mice are forced to swim in a restricted space, they will cease attempts to escape and adopt a characteristic immobile posture which can be readily indentified and timed. Imipramine decreased the duration of immobility in a 4 min swimming test in a dose-related manner. Likewise, caffeine, triiodothyronine and pentobarbital reduced immobility. These latter findings shed doubt upon the specificity of the behavior despair swimming test to identify substances with antidepressant activity. © 1979.
引用
收藏
页码：139 / 142
页数：4
相关论文
共 13 条
  • [1] BROWNE RG, 1979, FED PROC, V38, P861
  • [2] CONDITIONAL FEAR-INDUCED ANTINOCICEPTION AND DECREASED BINDING OF LEU-ENCEPHALIN-H-3 TO RAT-BRAIN
    CHANCE, WT
    WHITE, AC
    KRYNOCK, GM
    ROSECRANS, JA
    [J]. BRAIN RESEARCH, 1978, 141 (02) : 371 - 374
  • [3] COPPEN A, 1972, ARCH GEN PSYCHIAT, V26, P234
  • [4] GLUCKMAN MI, 1969, PSYCHOPHARMACOLOGIA, V15, P169
  • [5] HARVEY SC, 1975, PHARMACOL BASIS THER, P102
  • [6] STRESS-INDUCED PARALLEL CHANGES IN CENTRAL OPIOID LEVELS AND PAIN RESPONSIVENESS IN RAT
    MADDEN, J
    AKIL, H
    PATRICK, RL
    BARCHAS, JD
    [J]. NATURE, 1977, 265 (5592) : 358 - 360
  • [7] BEHAVIORAL DESPAIR IN RATS AND MICE - STRAIN DIFFERENCES AND EFFECTS OF IMIPRAMINE
    PORSOLT, RD
    BERTIN, A
    JALFRE, M
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 51 (03) : 291 - 294
  • [8] PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
  • [9] BEHAVIORAL DESPAIR IN RATS - NEW MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS
    PORSOLT, RD
    ANTON, G
    BLAVET, N
    JALFRE, M
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 47 (04) : 379 - 391
  • [10] DEPRESSION - NEW ANIMAL-MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS
    PORSOLT, RD
    LEPICHON, M
    JALFRE, M
    [J]. NATURE, 1977, 266 (5604) : 730 - 732
12