Background: Metformin is considered the first choice oral treatment for type 2 diabetes patients in the absence of contraindications. Rarely, life-threatening complications associated with metformin treatment are seen in some patients with underlying diseases. The aim of this study was to further investigate the clinical profiles and risk factors for metformin-associated lactic acidosis (MALA) and the treatment modalities according to survival. Methods: To identify MALA, we performed a retrospective study in seven diabetic patients who were taking metformin and had been diagnosed with lactic acidosis at Inha University Hospital between 1995 and 2012. For each patient, we recorded the age, sex, daily metformin dosage, laboratory test results, admission diagnosis, and risk factors. Also, concurrent conditions, treatment modalities, and outcomes were evaluated. Results: Six patients had risk factors for lactic acidosis before admission. All patients had renal impairment on admission as a precipitating risk factor. Five patients survived and two patients died despite early renal replacement therapy. Older patients tended to have a poorer prognosis. Conclusion: Renal function must be monitored in elderly type 2 diabetes mellitus patients with underlying diseases and conditions causing renal impairment who begin metformin treatment. Accurate recognition of MALA and initiation of renal replacement are essential for treatment.
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Dichtwald, S.
Weinbroum, A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Post Anesthesia Care Units, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Weinbroum, A. A.
Sorkine, P.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Sorkine, P.
Ekstein, M. P.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Intens Care, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Ekstein, M. P.
Dahan, E.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Intens Care, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Duong, Janna K.
Kumar, Shaun S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Kumar, Shaun S.
Kirkpatrick, Carl M.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Ctr Med Use & Safety, Melbourne, Vic 3004, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Kirkpatrick, Carl M.
Greenup, Louise C.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Greenup, Louise C.
Arora, Manit
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Arora, Manit
Lee, Toong C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sains Malaysia, George Town, MalaysiaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Lee, Toong C.
Timmins, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Bristol Myers Squibb, Drug Product Sciefnce & Technol, Moreton, Merseyside, EnglandUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Timmins, Peter
Graham, Garry G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Graham, Garry G.
Furlong, Timothy J.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Nephrol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Furlong, Timothy J.
Greenfield, Jerry R.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Endocrinol, Sydney, NSW 2010, Australia
Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Greenfield, Jerry R.
Williams, Kenneth M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Williams, Kenneth M.
Day, Richard O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Dichtwald, S.
Weinbroum, A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Post Anesthesia Care Units, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Weinbroum, A. A.
Sorkine, P.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Sorkine, P.
Ekstein, M. P.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Intens Care, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Ekstein, M. P.
Dahan, E.
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Intens Care, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Anesthesiol, IL-69978 Tel Aviv, Israel
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Duong, Janna K.
Kumar, Shaun S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Kumar, Shaun S.
Kirkpatrick, Carl M.
论文数: 0引用数: 0
h-index: 0
机构:
Monash Univ, Ctr Med Use & Safety, Melbourne, Vic 3004, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Kirkpatrick, Carl M.
Greenup, Louise C.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Greenup, Louise C.
Arora, Manit
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Arora, Manit
Lee, Toong C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sains Malaysia, George Town, MalaysiaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Lee, Toong C.
Timmins, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Bristol Myers Squibb, Drug Product Sciefnce & Technol, Moreton, Merseyside, EnglandUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Timmins, Peter
Graham, Garry G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Graham, Garry G.
Furlong, Timothy J.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Nephrol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Furlong, Timothy J.
Greenfield, Jerry R.
论文数: 0引用数: 0
h-index: 0
机构:
St Vincents Hosp, Dept Endocrinol, Sydney, NSW 2010, Australia
Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Greenfield, Jerry R.
Williams, Kenneth M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
Williams, Kenneth M.
Day, Richard O.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia
St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, AustraliaUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia