SUPERSELECTIVE INTRAARTERIAL CHEMOTHERAPY IN COMBINATION WITH IRRADIATION - PRELIMINARY-REPORT

被引：31

作者：

SHIMIZU, T

SAKAKURA, Y

HATTORI, T

YAMAGUCHI, N

KUBO, M

SAKAKURA, K

机构：

[1] Departments of Otorhinolaryngology and Radiology, Mie University School of Medicine, Tsu, Mie

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 1990年 / 11卷 / 02期

关键词：

head and neck cancer; intraarterial chemotherapy; radiotherapy;

D O I：

10.1016/0196-0709(90)90009-K

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Since 1984, a new method for the intraarterial administration of antineoplastic drugs, termed "superselective intraarterial chemotherapy," has been used in combination with simultaneous irradiation in the treatment of 49 patients with squamous cell carcinoma of the head and neck. Under the fluoroscope, a retrograde catheter is inserted into the superficial temporal artery and the tip is led selectively into the main feeding artery of the tumor. In our series of 49 patients, catheter-related complications occurred in only 12.5%. Forty-five patients (91.8%) completed more than 80% of the planned irradiation dosage. The therapeutic effect was excellent. The initial response rate was 100%. Systemic toxicity was uncommon, but local mucositis was frequent in the infused area. These results demonstrate that this new combined therapy is easy, safe, effective, and confers the highest possible initial response rate. © 1990.

引用

页码：131 / 136

页数：6

共 9 条

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