NUCLEOLAR ORGANIZER REGIONS IN PRECANCEROUS AND CANCEROUS LESIONS OF THE BRONCHUS

被引：0
|
作者：
ABE, S [1 ]
OGURA, S [1 ]
KUNIKANE, H [1 ]
SUKO, N [1 ]
WATANABE, N [1 ]
NAKAJIMA, I [1 ]
KAWAKAMI, Y [1 ]
INOUE, K [1 ]
机构：
[1] HOKKAIDO UNIV HOSP,DEPT PATHOL,SAPPORO,JAPAN
来源：
CANCER | 1991年 / 67卷 / 02期
关键词：
D O I：
10.1002/1097-0142(19910115)67:2<472::AID-CNCR2820670225>3.0.CO;2-N
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR in the nucleus were normal epithelium 1.2 +/- 0.1 (mean +/- SD), atypical squamaous metaplasia (borderline lesion) 2.2 +/- 0.5, carcinoma in situ 3.8 +/- 0.6, and microinvasive squamous cell carcinoma 4.8+/-1.1. There was a highly significant difference between the Ag-NOR numbers in the atypical squamous metaplasia and those in the carcinoma in situ (P < 0.01). The Ag-NOR staining is a useful technique for the differential diagnosis of difficult borderline lesions in the bronchial epithelium.
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收藏
页码：472 / 475
页数：4
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