INFLUENCE OF THYROTROPIN-RELEASING-HORMONE (TRH) AND HISTIDYL-PROLINE-DIKETOPIPERAZINE [CYCLO(HIS PRO)] ON ENZYME-SECRETION FROM ISOLATED RAT EXOCRINE PANCREATIC ACINAR-CELLS

被引：0
|
作者：
KEMMER, TP
DUNTAS, L
MUNZ, W
MALFERTHEINER, P
机构：
来源：
LEBER MAGEN DARM | 1994年 / 24卷 / 04期
关键词：
THYROTROPIN-RELEASING HORMONE (TRH); HISTIDYL-PROLINE DIKETOPIPERAZINE (CHP); PANCREAS; EXOCRINE SECRETION;
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The effect of thyrotropin-releasing hormone (TRH) and histidyl-proline-diketopiperazine [cyclo (His-Pro), CHP] on amylase secretion from isolated rat exocrine pancreatic acinar cells was investigated. TRH showed a dose-dependent inhibition of carbachol-stimulated amylase secretion with a maximum of 24% at a concentration of 10(-11) M (p < 0.05). Basal amylase release was not affected in concentrations from 10(-13) M to 10(-8) M. CHP did not influence basal or carbachol-stimulated pancreatic secretion in vitro. These results suggest that TRH in contrast to CHP may play a role in the paracrine regulation of exocrine pancreatic secretion.
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页码：156 / &
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