THE B-CELL ANTIGEN RECEPTOR OF THE 5 IMMUNOGLOBULIN CLASSES

被引：272

作者：

VENKITARAMAN, AR ^{[1
]}

WILLIAMS, GT ^{[1
]}

DARIAVACH, P ^{[1
]}

NEUBERGER, MS ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,IMMUNOGENET MOLEC LAB,F-34060 MONTPELLIER,FRANCE

来源：

NATURE | 1991年 / 352卷 / 6338期

关键词：

D O I：

10.1038/352777a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha-chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a common alpha/beta heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated alpha-chain and in their dependence on alpha/beta for surface transport.

引用

页码：777 / 781

页数：5

共 32 条

[1] IMMUNOGLOBULIN-D AND IMMUNOGLOBULIN-M MEDIATE SIGNALS THAT ARE QUALITATIVELY DIFFERENT IN B-CELLS WITH AN IMMATURE PHENOTYPE [J].

ALESMARTINEZ, JE ;

WARNER, GL ;

SCOTT, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6919-6923

[2] THE IMMUNOGENICITY OF CHIMERIC ANTIBODIES [J].

BRUGGEMANN, M ;

WINTER, G ;

WALDMANN, H ;

NEUBERGER, MS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) :2153-2157

[3] B-LYMPHOCYTE ANTIGEN RECEPTORS (MLG) ARE NON-COVALENTLY ASSOCIATED WITH A DISULFIDE LINKED, INDUCIBLY PHOSPHORYLATED GLYCOPROTEIN COMPLEX [J].

CAMPBELL, KS ;

CAMBIER, JC .

EMBO JOURNAL, 1990, 9 (02) :441-448

[4] DIFFERENCES IN GLYCOPROTEIN COMPLEXES ASSOCIATED WITH IGM AND IGD ON NORMAL MURINE B-CELLS POTENTIALLY ENABLE TRANSDUCTION OF DIFFERENT SIGNALS [J].

CHEN, JZ ;

STALL, AM ;

HERZENBERG, LA ;

HERZENBERG, LA .

EMBO JOURNAL, 1990, 9 (07) :2117-2124

[5] ISOLATION OF MONOCLONAL-ANTIBODIES SPECIFIC FOR HUMAN C-MYC PROTO-ONCOGENE PRODUCT [J].

EVAN, GI ;

LEWIS, GK ;

RAMSAY, G ;

BISHOP, JM .

MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (12) :3610-3616

[6] TYROSINE PHOSPHORYLATION OF COMPONENTS OF THE B-CELL ANTIGEN RECEPTORS FOLLOWING RECEPTOR CROSS-LINKING [J].

GOLD, MR ;

MATSUUCHI, L ;

KELLY, RB ;

DEFRANCO, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3436-3440

[7] A 30-KDA PROTEIN IS DISULFIDE LINKED TO IGM ON NORMAL AND NEOPLASTIC MURINE LYMPHOCYTES-B [J].

HAUSTEIN, D ;

VONDERAHE, D .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1986, 16 (01) :113-115

[8] B29 - A MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY EXCLUSIVELY EXPRESSED ON B-LINEAGE CELLS [J].

HERMANSON, GG ;

EISENBERG, D ;

KINCADE, PW ;

WALL, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6890-6894

[9] TRANSFECTED PLASMACYTOMA CELLS DO NOT TRANSPORT THE MEMBRANE FORM OF IGM TO THE CELL-SURFACE [J].

HOMBACH, J ;

SABLITZKY, F ;

RAJEWSKY, K ;

RETH, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (02) :652-657

[10] A NOVEL 34-KD PROTEIN CO-ISOLATED WITH THE IGM-MOLECULE IN SURFACE IGM-EXPRESSING CELLS [J].

HOMBACH, J ;

LECLERCQ, L ;

RADBRUCH, A ;

RAJEWSKY, K ;

RETH, M .

EMBO JOURNAL, 1988, 7 (11) :3451-3456

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