SOLUTION CONFORMATION OF ENDOTHELIN-3 BY H-1-NMR AND DISTANCE GEOMETRY CALCULATIONS

被引：34
作者：
BORTMANN, P
HOFLACK, J
PELTON, JT
SAUDEK, V
机构：
[1] Merrell Dow Research Institute, Strasbourg, 16, rue d'Ankara
来源：
NEUROCHEMISTRY INTERNATIONAL | 1991年 / 18卷 / 04期
关键词：
D O I：
10.1016/0197-0186(91)90145-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endothelin-3 dissolved in 10% aqueous acetic acid was studied by nuclear magnetic resonance spectroscopy. A total of 363 distances (143 intra-residue, 108 sequential and 112 long range) was compiled from the nuclear Overhauser effect spectra and used in distance calculations. The molecule assumes a compact conformation stabilized by hydrophobic interactions of the side chains. There is a helix-like structure between the residues 9-15 and an extended strand at the N-terminus. The C-terminus is in close proximity to the bicyclic ring.
引用
收藏
页码：491 / 496
页数：6
相关论文
共 50 条
[11]   THE SOLUTION CONFORMATION OF THE PEPTIDE ANTIBIOTIC THIOSTREPTON - A H-1-NMR STUDY [J].
HENSENS, OD ;
ALBERSSCHONBERG, G ;
ANDERSON, BF .
JOURNAL OF ANTIBIOTICS, 1983, 36 (07) :799-813
[12]   H-1-NMR SPECTRUM AND SOLUTION CONFORMATION OF ALBORIXIN FREE ACID [J].
RODIOS, NA ;
ANTEUNIS, MJO .
BULLETIN DES SOCIETES CHIMIQUES BELGES, 1979, 88 (05) :279-288
[13]   ASSIGNMENT AND CONFORMATION OF NEUROTENSIN IN AQUEOUS-SOLUTION BY H-1-NMR [J].
NIETO, JL ;
RICO, M ;
SANTORO, J ;
HERRANZ, J ;
BERMEJO, FJ .
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1986, 28 (03) :315-323
[14]   H-1-NMR SPECTRA AND CONFORMATION OF PUROMYCIN IN AQUEOUS-SOLUTION [J].
BERMEJO, FJ ;
GARCIA, J ;
MARTINEZ, E ;
RICO, M .
ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 1981, 77 (03) :398-404
[15]   DISTANCE GEOMETRY ANALYSIS OF THE NMR EVIDENCE ON THE SOLUTION CONFORMATION OF BLEOMYCIN [J].
CRIPPEN, GM ;
OPPENHEIMER, NJ ;
CONNOLLY, ML .
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1981, 17 (02) :156-169
[16]   THE CONFORMATION OF GLUCAGON IN DILUTE AQUEOUS-SOLUTION AS STUDIED BY H-1-NMR [J].
YI, GS ;
CHOI, BS ;
KIM, HM .
BIOCHEMISTRY INTERNATIONAL, 1992, 28 (03) :519-524
[17]   H-1-NMR STUDY ON THE CONFORMATION OF BACITRACIN-A IN AQUEOUS-SOLUTION [J].
KOBAYASHI, N ;
TAKENOUCHI, T ;
ENDO, S ;
MUNEKATA, E .
FEBS LETTERS, 1992, 305 (02) :105-109
[18]   SOLUTION 3-DIMENSIONAL STRUCTURE OF SURFACTIN - A CYCLIC LIPOPEPTIDE STUDIED BY H-1-NMR, DISTANCE GEOMETRY, AND MOLECULAR-DYNAMICS [J].
BONMATIN, JM ;
GENEST, M ;
LABBE, H ;
PTAK, M .
BIOPOLYMERS, 1994, 34 (07) :975-986
[19]   SOLUTION STRUCTURE OF ENDOTHELIN-3 DETERMINED USING NMR-SPECTROSCOPY [J].
MILLS, RG ;
ODONOGHUE, SI ;
SMITH, R ;
KING, GF .
BIOCHEMISTRY, 1992, 31 (24) :5640-5645
[20]   INVESTIGATION OF THE SOLUTION STRUCTURE OF THE HUMAN PARATHYROID-HORMONE FRAGMENT (1-34) BY H-1-NMR SPECTROSCOPY, DISTANCE GEOMETRY, AND MOLECULAR-DYNAMICS CALCULATIONS [J].
KLAUS, W ;
DIECKMANN, T ;
WRAY, V ;
SCHOMBURG, D ;
WINGENDER, E ;
MAYER, H .
BIOCHEMISTRY, 1991, 30 (28) :6936-6942
12345