SOLUTION CONFORMATION OF ENDOTHELIN-3 BY H-1-NMR AND DISTANCE GEOMETRY CALCULATIONS

被引：34
|
作者：
BORTMANN, P
HOFLACK, J
PELTON, JT
SAUDEK, V
机构：
[1] Merrell Dow Research Institute, Strasbourg, 16, rue d'Ankara
来源：
NEUROCHEMISTRY INTERNATIONAL | 1991年 / 18卷 / 04期
关键词：
D O I：
10.1016/0197-0186(91)90145-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endothelin-3 dissolved in 10% aqueous acetic acid was studied by nuclear magnetic resonance spectroscopy. A total of 363 distances (143 intra-residue, 108 sequential and 112 long range) was compiled from the nuclear Overhauser effect spectra and used in distance calculations. The molecule assumes a compact conformation stabilized by hydrophobic interactions of the side chains. There is a helix-like structure between the residues 9-15 and an extended strand at the N-terminus. The C-terminus is in close proximity to the bicyclic ring.
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收藏
页码：491 / 496
页数：6
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