INHIBITORY EFFECT OF CLINDAMYCIN ON PRODUCTION OF BETA-LACTAMASE IN BETA-LACTAM-RESISTANT BACTERIA

被引：0

作者：

NISHIHATA, T ^{[1
]}

KUNIEDA, S ^{[1
]}

NAKAHAMA, C ^{[1
]}

SOEJIMA, R ^{[1
]}

机构：

[1] KAWASAKI MED SCH, KURASHIKI, OKAYAMA 700, JAPAN

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1994年 / 17卷 / 05期

关键词：

BETA-LACTAMASE; CLINDAMYCIN; BETA-LACTAM ANTIBIOTICS; E-CLOACAE; PSEUDOMONAS-AERUGINOSA;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inhibitory effect of clindamycin on beta-lactamase biosynthesis was investigated in beta-lactam resistant bacteria with inducible and/or constitutive production of the enzyme(s). Clinical isolates of Enterobacter cloacae (E. cloacae) and Pseudomonas aeruginosa (P. aeruginosa) were examined. Three strains of each, against which sulbactam at 8 mug/ml reduced the minimum inhibitory concentration (MIC) of cefoperazone (CPZ) at least 4 fold, were studied in greater detail. Although clindamycin had no appreciable effect on bacteria growth at concentrations up to 50 mug/ml, it suppressed inducible beta-lactamase biosynthesis almost completely at a concentration of 20 mug/ml. There was also a significant reduction of constitutive enzyme biosynthesis by clindamycin at 50 mug/ml. Thus, it was estimated that a high concentration of clindamycin was required to suppress beta-lactamase biosynthesis in beta-lactamase producing bacteria of the constitutive type.

引用

页码：715 / 720

页数：6

共 23 条

[1] An enzyme from bacteria able to destroy penicillin [J].