THE EFFECTS OF THE SEROTONIN(1A) RECEPTOR AGONIST BUSPIRONE ON THE BLOOD-GLUCOSE AND PANCREATIC HORMONES IN RATS

被引：33

作者：

SUGIMOTO, Y ^{[1
]}

YAMADA, J ^{[1
]}

KIMURA, I ^{[1
]}

WATANABE, Y ^{[1
]}

HORISAKA, K ^{[1
]}

机构：

[1] KOBE WOMENS COLL PHARM,DEPT PHARMACOL,MOTOYAMAKITA MACHI,HIGASHINADA KU,KOBE 658,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 60卷 / 02期

关键词：

BUSPIRONE; SEROTONIN(1A) RECEPTOR; GLUCAGON;

D O I：

10.1254/jjp.60.145

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of the serotonin1A (5-HT1A) receptor agonist buspirone on the plasma glucose and pancreatic hormones insulin and glucagon were investigated in rats. Buspirone elicited significant hyperglycemia and hyperglucagonemia, although it did not affect the insulin levels. Adrenodemedullation inhibited both the increase in blood glucose and glucagon levels. These results indicate that buspirone-induced hyperglycemia and hyperglucagonemia are mediated by adrenaline release from the adrenal gland.

引用

页码：145 / 148

页数：4

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