ROLE OF THE CD45 TYROSINE PHOSPHATASE IN SIGNAL TRANSDUCTION IN THE IMMUNE-SYSTEM

被引：72

作者：

KORETZKY, GA ^{[1
]}

机构：

[1] UNIV IOWA,COLL MED,DEPT PHYSIOL & BIOPHYS,IOWA CITY,IA 52242

来源：

FASEB JOURNAL | 1993年 / 7卷 / 05期

关键词：

TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION; CD45; T-CELL RECEPTOR; TYROSINE KINASE;

D O I：

10.1096/fasebj.7.5.8462784

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD45, a family of hematopoietic cell specific surface antigens, is the best characterized protein tyrosine phosphatase described to date. Considerable evidence from a number of laboratories suggests that surface expression of this molecule is required for normal signaling events to occur in T lymphocytes, B lymphocytes, and natural killer cells. In this paper, data supporting this contention are reviewed and a model proposing how CD45 may exert its regulatory function on signal transduction via the T cell antigen receptor is presented.

引用

页码：420 / 426

页数：7

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