IMPROVED POSTHYPOXIC RECOVERY WITH A MEMBRANE-PERMEABLE CALPAIN INHIBITOR

被引：47
作者：
ARLINGHAUS, L
MEHDI, S
LEE, KS
机构：
[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL SURG,BOX 420,CHARLOTTESVILLE,VA 22908
[2] MARION MERRELL DOW RES INST,CINCINNATI,OH 45215
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 1-2期
关键词：
NEUROPROTECTION; CALPAIN INHIBITOR; HYPOXIA; HIPPOCAMPAL SLICE; PROTEOLYSIS; (RAT);
D O I：
10.1016/0014-2999(91)90022-I
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.
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收藏
页码：123 / 125
页数：3
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