COMPARATIVE-STUDY OF METABOLIC AND HORMONAL RESPONSES TO SOMATOSTATIN AND PROPRANOLOL IN MAN

被引:3
作者
GIUGLIANO, D
TORELLA, R
SGAMBATO, S
机构
[1] Instituto di Patologia Speciale Medica I Facoltà di Medicina, Università di Napoli, Napoli, 80100, Piazza L. Miraglia
来源
ACTA DIABETOLOGICA LATINA | 1979年 / 16卷 / 01期
关键词
FFA; Glucagon; Glucose; Growth hormone; Insulin; Propranolol; Somatostatin;
D O I
10.1007/BF02590766
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of this study was to compare the metabolic and hormonal effects of somatostatin to those of propranolol, a β-adrenergic blocking agent known to reduce basal insulin secretion. For this purpose, 6 normal subjects received somatostatin (4 μg/min) per 60 min and 6 subjects were infused with propranolol (0.08 mg/min). Somatostatin resulted in a significant decrease of basal insulin (p<0.05) and glucagon (p<0.01) and raised plasma FFA levels from a mean basal value of 417±24 μEq/l (x±SEM) to 600±46 μEq/l at 60 min (p<0.01). Propranolol significantly decreased basal insulin (p<0.05) and glucagon (p<0.05); FFA levels rose slightly at the end of propranolol administration (p>0.05). The levels of FFA which were significantly higher (p<0.025) during somatostatin as compared to those observed during propranolol, seem to suggest a role for this tetradecapeptide in lipid metabolism independent of its inhibiting action on islet hormone release. © 1979 Casa Editrice «il Ponte».
引用
收藏
页码:77 / 81
页数:5
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