Nitrated Proteome in Human Embryonic Stem Cells

被引：0
|
作者：
Kang, Jeong Won [1 ,2 ]
Hwang, Daehee [3 ,4 ]
Kim, Kwang Pyo [1 ]
机构：
[1] Kyung Hee Univ, Dept Appl Chem, Yoingin Si 17104, Gyeonggi Do, South Korea
[2] Natl Canc Ctr, Goyang Si 10408, Gyeonggi Do, South Korea
[3] DGIST, Inst Basic Sci, Dept New Biol, Daegu 42988, South Korea
[4] DGIST, Inst Basic Sci, Ctr Plant Aging Res, Daegu 42988, South Korea
来源：
MASS SPECTROMETRY LETTERS | 2016年 / 7卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Tyrosine nitration; Nitrotyrosine enrichment; LC-MS/MS; Proteomics; Embryonic stem cells;
D O I：
暂无
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Post-translational modifications (PTMs) of proteins regulate self-renewal and differentiation in embryonic stem cells (ESCs). Nitration of tyrosine residues of proteins in ESCs modulates their downstream pathways, which can affect self-renewal and differentiation. However, protein tyrosine nitration (PTN) in ESCs has been rarely studied. We reviewed 23 nitrated sites in stem cell proteins. Functional enrichment analysis showed that these nitrated proteins are involved in signal transduction, cell adhesion and migration, and cell proliferation in ESCs. Comparison between the nitrated and known phosphorylated sites revealed that 7 nitrated sites had overlapping phosphorylated sites, indicating functional links of PTNs to their associated signaling pathways in ESCs. Therefore, nitrated proteome provides a basis for understanding potential roles of PTN in self-renewal and differentiation of ESCs.
引用
收藏
页码：85 / 90
页数：6
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