UV SPECTROPHOTOMETRIC AND RP-HPLC ESTIMATION OF DRUG ASENAPINE IN TABLET DOSAGE FORM

被引：7

作者：

Borkar, A. A. ^{[1
]}

Gaikwad, N. J. ^{[1
]}

机构：

[1] Rashtrasant Tukadoji Maharaj Nagpur Univ, Dept Pharmaceut Sci, Futala Sq,Amravati Rd, Nagpur 440033, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2016年 / 7卷 / 07期

关键词：

Asenapine; Simultaneous estimation; UV-spectrophotometry; RP-HPLC; Recovery study;

D O I：

10.13040/IJPSR.0975-8232.7(7).3080-84

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Asenapine in Tablet dosage form is used as antipsychotic agent. Literature revealed that there is no single method for the simultaneous estimation of this drug in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive UV spectrophotometric and RP- HPLC methods. The simultaneous estimation of UV method is based on the principle of additivity of absorbance, for the determination of Asenapine in tablet formulation. The absorption maximum of the drug was found to be 270.0 nm in methanol. For RP- HPLC mobile phase is a mixture of acetonitrile and 0.1 M phosphate buffer (pH = 3.2) in the ratio of 65:35 v/v and detection wavelength is 270 nm. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.

引用

页码：3080 / 3084

页数：5