POSTNATAL-DEVELOPMENT OF NEUROGENIC INFLAMMATION IN THE RAT

被引：18

作者：

GONZALES, R

CODERRE, TJ

SHERBOURNE, CD

LEVINE, JD

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT ORAL & MAXILLOFACIAL SURG,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DIV NEUROSCI,SAN FRANCISCO,CA 94143

来源：

NEUROSCIENCE LETTERS | 1991年 / 127卷 / 01期

关键词：

NEUROGENIC INFLAMMATION; PLASMA EXTRAVASATION; SUBSTANCE-P; HISTAMINE; BRADYKININ; 6-HYDROXYDOPAMINE; SYMPATHETIC NERVOUS SYSTEM;

D O I：

10.1016/0304-3940(91)90885-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied the development in the rat of neurogenic inflammatory mechanisms that mediate cutaneous plasma extravasation. At birth and at postnatal day 10, intradermal injection of substance P, histamine, and bradykinin produced no significant plasma extravasation. At day 13 through adulthood (days 42-49), all test agents produced significant plasma extravasation which increased with increasing age. In the adult rat, pretreatment with 6-hydroxydopamine, to eliminate sympathetic postganglionic nerve terminals, attenuated the plasma extravasation elicited by substance P, histamine and bradykinin. The possible role of the sympathetic postganglionic neuron in the age-dependent changes in neurogenic inflammation is discussed.

引用

页码：25 / 27

页数：3

共 14 条

[1]

BLACK IB, 1984, CATECHOLAMINES BASIC, P31

[2] EVALUATION OF INCREASED VASCULAR PERMEABILITY IN SKIN OF GUINEA-PIGS [J].