EFFECT OF CHRONIC COCAINE ON DOPAMINE SYNTHESIS IN THE NUCLEUS-ACCUMBENS AS DETERMINED BY MICRODIALYSIS PERFUSION WITH NSD-1015

被引：46

作者：

BROCK, JW ^{[1
]}

NG, JP ^{[1
]}

JUSTICE, JB ^{[1
]}

机构：

[1] EMORY UNIV,DEPT CHEM,1515 PIERCE DR,ATLANTA,GA 30322

来源：

NEUROSCIENCE LETTERS | 1990年 / 117卷 / 1-2期

关键词：

Cocaine; DOPA; DOPAC; Dopamine; Microdialysis; NSD; 1015; Synthesis;

D O I：

10.1016/0304-3940(90)90150-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reduced steady state formation of dihydroxyphenylalanine (DOPA) (47%) was found in the nucleus accumbens (N. ACC) of rats treated with ten days of repeated cocaine (10 mg/kg, i.p.) as compared to saline controls after NSD 1015 perfusion (10-4 M) by microdialysis. In addition, prior to NSD 1015 perfusion, basal extracellular levels of the dopamine metabolite, dihydroxyphenylacetic acid (DOPAC) in the N. ACC were 33% lower in the chronic cocaine-treated animals. The results indicate the rate of dopamine synthesis in the N. ACC is significantly reduced by repeated cocaine administration. © 1990.

引用

页码：234 / 239

页数：6

共 9 条

[1] DETECTING BEHAVIORALLY RELEVANT CHANGES IN EXTRACELLULAR DOPAMINE WITH MICRODIALYSIS [J].