PLASMA CHOLESTEROL-PREDICTIVE EQUATIONS DEMONSTRATE THAT STEARIC-ACID IS NEUTRAL AND MONOUNSATURATED FATTY-ACIDS ARE HYPOCHOLESTEROLEMIC

被引：251
作者：
YU, SM
DERR, J
ETHERTON, TD
KRISETHERTON, PM
机构：
[1] PENN STATE UNIV,DEPT NUTR,UNIVERSITY PK,PA 16802
[2] PENN STATE UNIV,DEPT DAIRY & ANIM SCI,UNIVERSITY PK,PA 16802
[3] PENN STATE UNIV,DEPT STAT,UNIVERSITY PK,PA 16802
[4] PENN STATE UNIV,GRAD PROGRAM NUTR,UNIVERSITY PK,PA 16802
来源：
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1995年 / 61卷 / 05期
关键词：
SATURATED FATTY ACIDS; POLYUNSATURATED FATTY ACIDS; MONOUNSATURATED FATTY ACIDS; STEARIC ACID; PLASMA TOTAL CHOLESTEROL; HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL; LOW-DENSITY-LIPOPROTEIN CHOLESTEROL;
D O I：
10.1093/ajcn/61.5.1129
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
In the present study we used regression analyses to evaluate the effects of stearic acid (18:0) on total cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), and high-density-lipoprotein-cholesterol (HDL-C) concentrations (mmol/L). Using data from 18 articles, we developed the following predictive equations (monounsaturated fatty acids, MUFAs; polyunsaturated fatty acids, PUFAs): Delta TC = 0.0522 Delta 12:0-16:0 - 0.0008 Delta 18:0 - 0.0124 Delta MUFA - 0.0248 Delta PUFA; Delta LDL-C = 0.0378 Delta 12:0-16:0 + 0.0018 Delta 18:0 - 0.0178 Delta MUFA - 0.0248 Delta PUFA; Delta HDL-C = 0.0160 Delta 12:0-16:0 - 0.0016 Delta 18:0 + 0.0101 Delta MUFA + 0.0062 Delta PUFA. Our analyses revealed that unlike the other long-chain saturated fatty acids (SFAs), stearic acid had no effect on TC and lipoprotein cholesterol concentrations in men and women. MUFAs elicited an independent hypocholesterolemic effect that we believe is due to the small amount of 12:0-16:0 in the experimental diets evaluated. The observation that stearic acid has unique effects on TC, LDL-C, and HDL-C provides additional compelling evidence that it be distinguished from the other major SFAs in blood cholesterol predictive equations.
引用
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页码：1129 / 1139
页数：11
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