A SEQUENTIAL DOUBLE-BLIND CONTROLLED-STUDY OF MOCLOBEMIDE AND MIANSERIN IN ELDERLY DEPRESSED-PATIENTS

Moclobemide was compared with mianserin in a double‐blind controlled study in elderly depressed patients. Sequential analysis of 11 pairs of patients found no significant difference between the drugs at the week 8 analysis. Unpaired comparison of the 26 patients completing four weeks' treatment also showed no significant difference between the two drugs. Both drugs significantly reduced Hamilton and Carroll depression rating scroes. A separate analysis of the 20 patients completing eight weeks' treatment showed that both drugs produced significant decreases in Hamilton and Carroll depression ratings with no significant difference between the two drugs for depression scores at either week 4 or 8. Side‐effects were minimal, with the most severe emergent side‐effects for moclobemide being sleep disturbance, blurred vision and dry mouth. Copyright © 1990 John Wiley & Sons, Ltd.