Ethyl 2-[4-(morpholin-4-yl) phenyl]-1-[3-(2-oxopyrrolidin-1-yl)propyl]-1H-1,3-benzimidazole-5-carboxylate monohydrate

The asymmetric unit of the title compound, C27H32N4O4 center dot H2O, contains two independent benzimidazole-5-carboxylate molecules and two water molecules. In both main molecules, the pyrrolidine rings are in an envelope conformation with a methylene C atom as the flap. The morpholine rings adopt chair conformations. Both benzimidazole rings are essentially planar, with maximum deviations of 0.008 (1) angstrom, and form dihedral angles of 37.65 (6) and 45.44 (6)degrees with the benzene rings. In one molecule, an intramolecular C-H center dot center dot center dot O hydrogen bond forms an S(7) ring motif. In the crystal, O-H center dot center dot center dot O and O-H center dot center dot center dot N hydrogen bonds connect pairs of main molecules and pairs of water molecules into two independent centro-symmetric four-compoment aggregates. These aggregates are connect by C-H center dot center dot center dot O hydrogen bonds leading to the formation of a three-dimensional network, which is stabilized by C-H center dot center dot center dot pi interactions.