ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES

被引：0
作者：
MIZUSHIMA, Y
KASHII, T
KOBAYASHI, M
机构：
来源：
ONCOLOGY REPORTS | 1995年 / 2卷 / 02期
关键词：
K-RAS; P53; N-MYC; LUNG CANCER; DRUG SENSITIVITY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The association between gene alterations (K-ras, p53, N-myc) and drug resistance (CDDP, CBDCA, MMC, Epi-ADM) was examined in 29 human lung carcinoma cell lines using the in vitro MTT assay. There was no significant difference in the IC50 values of four drugs between K-ras or p53 gene alteration-positive and -negative groups. However, two cell lines with N-myc amplification showed a higher resistance than those without N-myc amplification to all four drugs. This preliminary study suggests that K-ras or p53 gene alteration is probably not related to drug resistance, but N-myc might be.
引用
收藏
页码：277 / 280
页数：4
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