ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES

被引：0

作者：

MIZUSHIMA, Y

KASHII, T

KOBAYASHI, M

机构：

来源：

ONCOLOGY REPORTS | 1995年 / 2卷 / 02期

关键词：

K-RAS; P53; N-MYC; LUNG CANCER; DRUG SENSITIVITY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The association between gene alterations (K-ras, p53, N-myc) and drug resistance (CDDP, CBDCA, MMC, Epi-ADM) was examined in 29 human lung carcinoma cell lines using the in vitro MTT assay. There was no significant difference in the IC50 values of four drugs between K-ras or p53 gene alteration-positive and -negative groups. However, two cell lines with N-myc amplification showed a higher resistance than those without N-myc amplification to all four drugs. This preliminary study suggests that K-ras or p53 gene alteration is probably not related to drug resistance, but N-myc might be.

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页码：277 / 280

页数：4

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