EFFECT OF LY-171555 AND CY-208-243 ON TREMOR SUPPRESSION IN THE MPTP MONKEY MODEL OF PARKINSONISM

被引：10

作者：

GOMEZMANCILLA, B ^{[1
]}

BOUCHER, R ^{[1
]}

BEDARD, PJ ^{[1
]}

机构：

[1] HOP ENFANTS JESUS,CTR RECH NEUROBIOL,1401 18 RUE,QUEBEC CITY G1J 1Z4,QUEBEC,CANADA

来源：

MOVEMENT DISORDERS | 1992年 / 7卷 / 01期

关键词：

LY-171555; D2; AGONIST; CY-208-243; D1; MONKEY; PARKINSONISM; MPTP; TREMOR;

D O I：

10.1002/mds.870070108

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208-243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest tremor in the limbs. The D2 agonist suppressed rest tremor in a dose-dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.

引用

页码：43 / 47

页数：5

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