ACTIN-BASED BACTERIAL MOTILITY

被引：94
作者：
COSSART, P
机构：
[1] Institut Pasteur, Paris
来源：
CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 01期
关键词：
D O I：
10.1016/0955-0674(95)80050-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Listeria monocytogenes and other bacterial pathogens move in the host cell cytoplasm, propelled by continuous actin assembly at one pole of the bacterium. This actin-based motility requires the presence of the bacterial proteins ActA on L. monocytogenes and. IcsA on Shigella flexneri. There have been several major discoveries in the past year: the discovery of the polar distribution of ActA and IcsA on the bacterial surface; the demonstration that bacterial ActA is phosphorylated in infected host cells; the involvement of some host cell proteins, particularly profilin; and the dramatic effect of ActA expression in transfected eukaryotic cells. A cell-free system that reconstitutes faithfully the actin-based motility of L. monocytogenes promises to be instrumental in the further dissection of this fascinating phenomenon.
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页码：94 / 101
页数：8
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