EFFECTS OF SODIUM PENTOTHAL AND SUFENTANIL ON SEROTONIN INDUCED CONSTRICTION OF CANINE CORONARY-ARTERY RINGS WITHOUT ENDOTHELIUM

被引：7
作者：
INTRONA, RPS
PRUETT, JK
MARTIN, DC
JOSEPHSON, D
MANABE, M
机构：
[1] Department of Anesthesiology, Medical College of Georgia, Augusta
来源：
GENERAL PHARMACOLOGY | 1991年 / 22卷 / 04期
关键词：
D O I：
10.1016/0306-3623(91)90061-A
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The individual and combined effects of sufentanil and sodium pentothal on canine coronary artery vasomotor responses to 5-HT were studied in an isolated vascular ring preparation. 2. Clinical concentrations of sufentanil have little effect on basal coronary tension or constriction induced by either 5-HT or sodium pentothal individually, until very high doses > 0.26-mu-M are reached. 3. Sodium pentothal causes coronary constriction at clinical concentrations and this effect is additive and possibly potentiated when combined with 5-HT. 4. Sufentanil inhibits coronary constriction induced by the combination of sodium pentothal and 5-HT.
引用
收藏
页码：589 / 594
页数：6
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