EFFECT OF EPIDERMAL GROWTH-FACTOR (EGF) ON GLUCONEOGENESIS IN ISOLATED RAT HEPATOCYTES - DEPENDENCY ON THE RED-OX STATE OF THE SUBSTRATE

被引：9
|
作者：
SOLER, C [1 ]
POVEDA, B [1 ]
PASTORANGLADA, M [1 ]
SOLEY, M [1 ]
机构：
[1] UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & FISIOL,UNITAT BIOQUIM & BIOL MOLEC B,DIAGONAL 645,E-08071 BARCELONA,SPAIN
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1091卷 / 02期
关键词：
EPIDERMAL GROWTH FACTOR; GLUCONEOGENESIS; REDOX; (HEPATOCYTE);
D O I：
10.1016/0167-4889(91)90061-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It was found that EGF decreased both the basal- and the glucagon-stimulated gluconeogenesis from lactate alone or from a high lactate/pyruvate ratio and that it enhanced both the basal- and the glucagon-inhibited glucose synthesis from pyruvate alone or from a low lactate/pyruvate ratio. These findings demonstrate that the effect of both EGF and glucagon on glucose production by isolated hepatocytes depends on the red-ox state of the substrate.
引用
收藏
页码：193 / 196
页数：4
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