A HUMAN ADP ATP TRANSLOCASE GENE HAS 7 PSEUDOGENES AND LOCALIZES TO CHROMOSOME-X

被引：29

作者：

CHEN, ST ^{[1
]}

CHANG, CD ^{[1
]}

HUEBNER, K ^{[1
]}

KU, DH ^{[1
]}

MCFARLAND, M ^{[1
]}

DERIEL, JK ^{[1
]}

BASERGA, R ^{[1
]}

WURZEL, J ^{[1
]}

机构：

[1] TEMPLE UNIV,HLTH SCI CTR,SCH MED,FELS INST CANC RES & MOLEC BIOL,PHILADELPHIA,PA 19140

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1990年 / 16卷 / 02期

关键词：

D O I：

10.1007/BF01233044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are at least three transcriptionally active human ADP/ATP translocase genes. We have isolated seven ADP/ATP translocase pseudogenes from recombinant human genomic libraries. Each pseudogene sequence had more than 85% identity with the sequence of the human ADP/ATP translocase cDNA derived from fibroblast mRNA, but each had mutations that precluded synthesis of a functional protein. Using an intro probe derived from a partial clone of the human fibroblast ADP/ATP translocase gene, we localized the gene to chromosome Xq13 → Xq25-26. The gene encoding the skeletal muscle translocase has previously been shown to be on chromosome 4. Therefore, the human ADP/ATP translocase genes are members of a multigene family that includes pseudogenes and has been dispersed to at least two chromosomes. © 1990 Plenum Publishing Corporation.

引用

页码：143 / 149

页数：7

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