PROGNOSTIC-SIGNIFICANCE OF PS2 PROTEIN EXPRESSION IN PULMONARY ADENOCARCINOMA

被引：23

作者：

HIGASHIYAMA, M ^{[1
]}

DOI, O ^{[1
]}

KODAMA, K ^{[1
]}

YOKOUCHI, H ^{[1
]}

INAJI, H ^{[1
]}

NAKAMORI, S ^{[1
]}

TATEISHI, R ^{[1
]}

机构：

[1] CTR ADULT DIS, DEPT PATHOL, OSAKA 537, JAPAN

来源：

EUROPEAN JOURNAL OF CANCER | 1994年 / 30A卷 / 06期

关键词：

PULMONARY ADENOCARCINOMA; PS2; PROTEIN; IMMUNOHISTOCHEMISTRY; PROGNOSIS;

D O I：

10.1016/0959-8049(94)90294-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present study, pS2 protein expression in pulmonary adenocarcinoma was investigated on paraffin-embedded sections obtained from 170 patients. 28 (16%) patients showed varying degrees of pS2 protein expression in the cytoplasm of tumour cells, as detected by immunohistochemical staining with anti-pS2 protein antibody. There was a significant association between pS2 protein expression and larger tumour size, and the acinar or bronchiolo-alveolar subtype. However, no significant correlations between pS2 protein status and the other clinicopathological factors, i.e. T-factor, N-factor, stage and histological differentiation, were shown. In contrast to breast cancer, patients with pS2-positive pulmonary adenocarcinomas had a significantly worse prognosis than those with pS2-negative pulmonary adenocarcinomas; this was true for stage I patients, as well as for all patients. Multivariate analysis showed that pS2 protein expression was a discriminating variable in overall survival. These findings suggest that pS2 protein status is a possible prognostic indicator in pulmonary adenocarcinoma.

引用

页码：792 / 797

页数：6

共 30 条

[1] PROGNOSTIC RELEVANCE OF PS2-STATUS IN ASSOCIATION WITH STEROID-RECEPTOR STATUS AND PROLIFERATIVE ACTIVITY IN NODE-NEGATIVE BREAST-CANCER [J].