EFFECTS OF FLEZELASTINE AND ITS ENANTIOMERS ON LPS-INDUCED IL-1-BETA GENERATION IN-VITRO AND LPS-INDUCED PYREXIA IN-VIVO

The effects of the novel antiasthmatic/antiallergic compound flezelastine on LPS-induced actions were investigated in vitro and in vivo. In monocytes, IL-1 beta generation stimulated by LPS was inhibited dose dependently. In vivo, LPS-induced fever in rats, which is at least partly driven by the release of IL-1 beta, was also inhibited by flezelastine. These findings suggest that flezelastine inhibits IL-1 synthesis and/or release in vitro and in vivo.