BIODEGRADATION OF A POLY(ALPHA-AMINO ACID) HYDROGEL .1. INVIVO

被引：59

作者：

DICKINSON, HR ^{[1
]}

HILTNER, A ^{[1
]}

GIBBONS, DF ^{[1
]}

ANDERSON, JM ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT MACROMOLEC SCI,CLEVELAND,OH 44106

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1981年 / 15卷 / 04期

关键词：

BIOMEDICAL ENGINEERING - Surgical Implants - ENZYMES AND ENZYME TECHNOLOGY - PROTEINS - Hydrolysis;

D O I：

10.1002/jbm.820150412

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new hydrogel material has been prepared by crosslinking a hydrophilic, m nonionic poly(amino acid), poly(2-hydroxyethyl-L-glutamine). The material properties of the hydrogel can be controlled by variation in the crosslink density, and the swelling ratio was found to be a sensitive and convenient method for measuring the extent of in vivo biodegradation of implanted specimens. Degradation of the material was observed only during the first 2 weeks of subcutaneous implantation in rats, and is attributed to hydrolysis by proteolytic enzymes released during the acute and chronic stages of the normal inflammatory response.

引用

页码：577 / 589

页数：13

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