BLEOMYCIN-DETECTABLE IRON IN THE PLASMA OF PREMATURE AND FULL-TERM NEONATES

被引：86
作者：
EVANS, PJ
EVANS, R
KOVAR, IZ
HOLTON, AF
HALLIWELL, B
机构：
[1] UNIV CALIF DAVIS, SACRAMENTO MED CTR, DIV PULM CRIT CARE MED, SACRAMENTO, CA 95817 USA
[2] UNIV LONDON KINGS COLL, DEPT BIOCHEM, LONDON WC2R 2LS, ENGLAND
[3] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP, DEPT BIOCHEM, LONDON SE1 9RT, ENGLAND
[4] CHARING CROSS & WESTMINSTER MED SCH, DEPT CHILD HLTH, LONDON W6 8RF, ENGLAND
[5] LEICESTER ROYAL INFIRM, DEPT CHILD HLTH, LEICESTER LE1 5WW, ENGLAND
来源：
FEBS LETTERS | 1992年 / 303卷 / 2-3期
关键词：
NEONATE; BLEOMYCIN; IRON OVERLOAD; IRON METABOLISM; TRANSFERRIN; FREE RADICAL;
D O I：
10.1016/0014-5793(92)80521-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full-term apparently-healthy babies may be at risk of severe oxidative damage.
引用
收藏
页码：210 / 212
页数：3
相关论文
共 24 条
[1]   SUPEROXIDE-DEPENDENT AND ASCORBATE-DEPENDENT FORMATION OF HYDROXYL RADICALS FROM HYDROGEN-PEROXIDE IN THE PRESENCE OF IRON - ARE LACTOFERRIN AND TRANSFERRIN PROMOTERS OF HYDROXYL-RADICAL GENERATION [J].
ARUOMA, OI ;
HALLIWELL, B .
BIOCHEMICAL JOURNAL, 1987, 241 (01) :273-278
[2]   AN EVALUATION OF THE ANTIOXIDANT AND POTENTIAL PRO-OXIDANT PROPERTIES OF FOOD-ADDITIVES AND OF TROLOX-C, VITAMIN-E AND PROBUCOL [J].
ARUOMA, OI ;
EVANS, PJ ;
KAUR, H ;
SUTCLIFFE, L ;
HALLIWELL, B .
FREE RADICAL RESEARCH COMMUNICATIONS, 1990, 10 (03) :143-157
[3]  
ARUOMA OI, 1988, BLOOD, V72, P1416
[4]   IRON OVERLOAD, FREE-RADICAL DAMAGE, AND RHESUS HEMOLYTIC-DISEASE [J].
BERGER, HM ;
LINDEMAN, JHN ;
VANZOERENGROBBEN, D ;
HOUDKAMP, E ;
SCHRIJVER, J ;
KANHAI, HH .
LANCET, 1990, 335 (8695) :933-936
[5]  
CURNUTTE JT, 1987, ADV HUM GENET, V16, P229
[6]   STUDIES OF BINDING OF DIFFERENT IRON DONORS TO HUMAN-SERUM TRANSFERRIN AND ISOLATION OF IRON-BINDING FRAGMENTS FROM N-TERMINAL AND C-TERMINAL REGIONS OF PROTEIN [J].
EVANS, RW ;
WILLIAMS, J .
BIOCHEMICAL JOURNAL, 1978, 173 (02) :543-552
[7]   DEVELOPMENTAL ASPECTS OF EXPERIMENTAL PULMONARY OXYGEN-TOXICITY [J].
FRANK, L .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 11 (05) :463-494
[8]   INHIBITION OF LIPID-PEROXIDATION BY THE IRON-BINDING PROTEIN LACTOFERRIN [J].
GUTTERIDGE, JMC ;
PATERSON, SK ;
SEGAL, AW ;
HALLIWELL, B .
BIOCHEMICAL JOURNAL, 1981, 199 (01) :259-261
[9]   SUPEROXIDE-DEPENDENT FORMATION OF HYDROXYL RADICALS IN THE PRESENCE OF IRON SALTS - DETECTION OF FREE IRON IN BIOLOGICAL-SYSTEMS BY USING BLEOMYCIN-DEPENDENT DEGRADATION OF DNA [J].
GUTTERIDGE, JMC ;
ROWLEY, DA ;
HALLIWELL, B .
BIOCHEMICAL JOURNAL, 1981, 199 (01) :263-265
[10]  
GUTTERIDGE JMC, 1987, LIFE CHEM REPORTS, V4, P113
123