PARTITION-COEFFICIENT AS A GUIDE TO THE DEVELOPMENT OF RADIOSENSITIZERS WHICH ARE LESS TOXIC THAN MISONIDAZOLE

被引：202
作者：
BROWN, JM [1 ]
WORKMAN, P [1 ]
机构：
[1] MED SCH CAMBRIDGE,MRC,CLIN ONCOL & RADIOTHERAPEUT UNIT,CAMBRIDGE,ENGLAND
来源：
RADIATION RESEARCH | 1980年 / 82卷 / 01期
关键词：
D O I：
10.2307/3575246
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：171 / 190
页数：20
相关论文
共 31 条
[1]   STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE DEVELOPMENT OF HYPOXIC CELL RADIOSENSITIZERS .1. SENSITIZATION EFFICIENCY [J].
ADAMS, GE ;
CLARKE, ED ;
FLOCKHART, IR ;
JACOBS, RS ;
SEHMI, DS ;
STRATFORD, IJ ;
WARDMAN, P ;
WATTS, ME ;
PARRICK, J ;
WALLACE, RG ;
SMITHEN, CE .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1979, 35 (02) :133-150
[2]  
ADAMS GE, 1977, CANCER COMPREHENSIVE, V6, P181
[3]   EFFECT OF LIPOPHILICITY OF NITROIMIDAZOLES ON RADIOSENSITIZATION OF HYPOXIC BACTERIAL-CELLS INVITRO [J].
ANDERSON, RF ;
PATEL, KB .
BRITISH JOURNAL OF CANCER, 1979, 39 (06) :705-710
[4]  
BINNS TB, 1964, ABSORPTION DISTRIBUT
[5]  
BRADBURY MW, 1964, ABSORPTION DISTRIBUT, P77
[6]  
BROWN JM, 1978, BRIT J CANCER, V37, P206
[7]   PHARMACOKINETIC CONSIDERATIONS IN TESTING HYPOXIC CELL RADIOSENSITIZERS IN MOUSE-TUMORS [J].
BROWN, JM ;
YU, NY ;
WORKMAN, P .
BRITISH JOURNAL OF CANCER, 1979, 39 (03) :310-320
[8]  
BROWN JM, CANCER CLIN TRIALS
[9]   NITROIMIDAZOLE DERIVATIVES . RELATIONSHIP BETWEEN STRUCTURE AND ANTITRICHOMONAL ACTIVITY [J].
BUTLER, K ;
HOWES, HL ;
LYNCH, JE ;
PIRIE, DK .
JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (05) :891-&
[10]   MISONIDAZOLE NEUROTOXICITY IN THE MOUSE - EVALUATION OF FUNCTIONAL, PHARMACOKINETIC, ELECTROPHYSIOLOGIC AND MORPHOLOGIC PARAMETERS [J].
CONROY, PJ ;
VONBURG, R ;
PASSALACQUA, W ;
PENNEY, DP ;
SUTHERLAND, RM .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1979, 5 (07) :983-991
1234