CONVULSANTS INDUCE INTERLEUKIN-1-BETA MESSENGER-RNA IN RAT-BRAIN

被引：149

作者：

MINAMI, M

KURAISHI, Y

YAMAGUCHI, T

NAKAI, S

HIRAI, Y

SATOH, M

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KYOTO 606,JAPAN

[2] OTSUKA PHARMACEUT CO LTD,INST CELLULAR TECHNOL,TOKUSHIMA 77101,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)91221-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of systemic administration of kainic acid and pentylenetetrazol on interleukin-1β gene expression in the rat brain was studied. After the administration of kainic acid in a convulsive dose (10 mg/kg i.p.), Interleukin-1β mRNA was induced intensely in the cerebral cortex, thalamus and hypothalamus, moderately in the hippocampus and weakly in the striatum, but not in the midbrain, pons-medulla and cerebellum. Pentylenetetrazol induced Interleukin-1β mRNA in the cerebral cortex, hypothalamus, and hippocampus with a faster time-course than kainic acid. Diazepam suppressed both the convulsion and the induction of Interleukin-1β mRNA produced by kainic acid. Dexamethasone suppressed the induction of Interleukin-1β mRNA, but did neither the convulsion nor the induction of c-fos mRNA following the injection of kainic acid. These results provide the first evidence that intensive neuronal excitation induces Interleukin-1β mRNA in particular regions of the brain. © 1990.

引用

页码：832 / 837

页数：6

共 24 条

[1] ELECTROGRAPHIC, CLINICAL AND PATHOLOGICAL ALTERATIONS FOLLOWING SYSTEMIC ADMINISTRATION OF KAINIC ACID, BICUCULLINE OR PENTETRAZOLE - METABOLIC MAPPING USING THE DEOXYGLUCOSE METHOD WITH SPECIAL REFERENCE TO THE PATHOLOGY OF EPILEPSY [J].