SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW DIARYLSULFIDES AND DIARYLSULFONES CONTAINING AMINO-ACID MOIETIES .1.

4′-Nitro-4-aminodiphenylsulphide (la) and/or 2’-nitro-4-amino-diphenylsulphide (lb) react with chloroacetylchloride giving 4-chloroacetylamino-diarylsulphides (2 a, b) which undergo facile reaction with different amines and hydrazine yielding the 4-glycylamino and 4-hydrazinoacetylaminodiphenylsulphides (3) and (5). Two moles of 2 react with one mole of piperazine and/or hydrazine to give l, 4-Bis(p-N-(p’-nitrodiphenylsulphido)(amino-carbonylmethylene)piperazine (4) and l, 2-Bis(p-N-(o’-nitro-diphenylsulphido)(aminocar-bonylmethylene)hydrazine (6). On condensation of 5 with aromatic aldehydes yielded new Schiff bases (7). Oxidation of 3, 4, 6 and 7 using H2O2/CH3COOH mixtures furnished the corresponding diarylsulphones 8, 9, 10 and 11, respectively. The biological activity of some of the prepared compounds were screened against some strains of bacteria. © 1979, Walter de Gruyter. All rights reserved.