STANDARDIZED MENTAL STRESS IN HEALTHY-VOLUNTEERS INDUCED BY DELAYED AUDITORY-FEEDBACK (DAF)

被引：23

作者：

BADIAN, M

APPEL, E

PALM, D

RUPP, W

SITTIG, W

TAEUBER, K

机构：

[1] UNIV FRANKFURT KLINIKUM,ZENTRUM PHARMAKOL,ABT 6,D-6000 FRANKFURT,FED REP GER

[2] HOECHST AG,DEPT MED,CLIN PHARMACOL,D-6230 FRANKFURT 80,FED REP GER

[3] UNIV FRANKFURT,DEPT PHARMACOL,D-6000 FRANKFURT 70,FED REP GER

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 16卷 / 03期

关键词：

delayed auditory feedback; mental stress; plasma dopamine-beta-hydroxylase; plasma epinephrine; plasma norepinephrine; sympathetic activation;

D O I：

10.1007/BF00562057

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using delayed auditory feedback (delay 0.175 s) a standardized form of mental stress was investigated in 8 healthy male volunteers. After a resting period and a period of undelayed reading, the volunteers were exposed for 5 min to the DAF stress. During the DAF period heart rate increased by 10% and systolic and diastolic blood pressure increased by 9% and 18%, respectively. As a measure of acute sympathetic activation, plasma concentrations of norepinephrine and epinephrine rose by 68% and 49%, respectively. The activity of dopamine-β-hydroxylase in plasma was increased by 25%. From these results it can be concluded that the DAF procedure provides a suitable method for inducing a standardized mental stress in normal subjects, which can be measured as changes in biochemical and cardiovascular variables. © 1979 Springer-Verlag.

引用

页码：171 / 176

页数：6

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