Optical Molecular Imaging for Diagnosing Intestinal Diseases

被引：13

作者：

Kim, Sang-Yeob ^{[1
]}

Myung, Seung-Jae ^{[1
,2
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Asan Inst Life Sci, Seoul, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, 88 Olymp Ro 43 Gil, Seoul 138736, South Korea

来源：

CLINICAL ENDOSCOPY | 2013年 / 46卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Molecular imaging; Endoscopy; Fluorescence probe; Intestinal diseases;

D O I：

10.5946/ce.2013.46.6.620

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Real-time visualization of the molecular signature of cells can be achieved with advanced targeted imaging techniques using molecular probes and fluorescence endoscopy. This molecular optical imaging in gastrointestinal endoscopy is promising for improving the detection of neoplastic lesions, their characterization for patient stratification, and the assessment of their response to molecular targeted therapy and radiotherapy. In inflammatory bowel disease, this method can be used to detect dysplasia in the presence of background inflammation and to visualize inflammatory molecular targets for assessing disease severity and prognosis. Several preclinical and clinical trials have applied this method in endoscopy; however, this field has just started to evolve. Hence, many problems have yet to be solved to enable the clinical application of this novel method.

引用

页码：620 / 626

页数：7

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